In the case of the man in France who developed the strange rash, the doctors also found that he had a blood disease called periarteritis nodosa (PAN), in which small arteries become swollen and damaged. The man recovered in five days, after doctors treated him with oral corticosteroids. Other reports have also linked AGEP to brown recluse spider bites, the researchers said. The medical staff diagnosed the man with a condition called acute generalized exanthematous pustulosis (AGEP), which typically occurs in people taking antibiotics. The man had pinhead-size bumps on his forearms, which later spread to other parts of his body. A 66-year-old patient in France developed a strange rash after being bitten by a spider, which the doctors suspected was likely a brown recluse spider, according to a report of his case. Some people develop unpredictable skin reactions to spider bites. Part of her ear turned black, and her doctor had to remove the dead tissue and restore it, using cartilage from the woman's ribs. One such case was reported last year - a woman on vacation in Italy developed necrosis in her ear after being bitten by a brown recluse spider. When necrosis does occur, tissue may sometimes turn black as cells die. The only spider in North America whose bites have been shown to kill human tissue in rare instances is the brown recluse spider, Vetter said. If a spider bite is "verified," it means that there was actual evidence that a person was bitten by a particular kind of spider. (Toxinology is the study of the venoms and poisons of plants, animals and microbes it is different from toxicology, which is the study of chemicals and drugs as they affect the body.) Scott Weinstein, a toxinologist at Women's and Children's Hospital in North Adelaide, South Australia, told Live Science. In fact, researchers estimate that less than one case of dead human tissue is reported per 5,000 spider bites from verified spider specimens, and verification of spider bites is very rare, Dr. Dead tissueĪlthough there have been cases of "necrotic arachnidism," in which spider venom kills human tissue, such cases are extremely rare. Although the creepy crawler's size may make it look threatening, it is not aggressive and, like most spiders, will only attack when it feels threatened, experts say. The Brazilian wandering spider is large, with a body size reaching up to 2 inches (5 centimeters) and leg spans stretching 5 or 6 inches (13 to 15 cm). Researchers have since tested the toxin that is responsible for this unusual effect, called PnTx2-6, in the hope of developing a potential new drug for erectile dysfunction. The effect happens because the spider's venom raises the levels of nitric oxide, which is a chemical that increases blood flow. In 2007, researchers found that the bites of the Brazilian wandering spider can cause long and painful erections in human males, along with other symptoms. The Brazilian wandering spider's venom contains a toxin whose unusual erection-inducing qualities have attracted the attention of the pharmaceutical industry. Here are some of the weirdest effects spider bites have had on people.
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